亚盛医药全球战略合作伙伴UNITY Biotechnology的研究工作获评科学杂志2016年年度五大技术突破之一

细胞衰老（cellular senescence）是指细胞采取一种生物学紧急刹车机制以停止分裂。这是一种重要的抗肿瘤机制，因为它可防止细胞发生失控性的繁殖。但在刹车被踩停后，衰老细胞仍然停留在机体内，随着时间推移不断累积。与正常细胞不同，这些细胞会分泌有害的炎症分子，进而侵袭其周围细胞和组织1。

Cellular senescence is a biological “emergency brake” cells use to stop dividing.  It’s an important anti-tumor mechanism, because it prevents cells from multiplying out of control. But after this “brake” has been pulled, senescent cells remain in the body, accumulating with age. And unlike normal cells, these cells secrete inflammatory molecules that harm neighboring cells and tissues.1

UNITY公司已在动物模型研究中证实选择性清除衰老细胞可以反转甚至预防一系列疾病，这些疾病包括骨关节炎、动脉粥样硬化、眼部疾病及肾脏疾病1。

UNITY has demonstrated in animal models that selectively eliminating senescent cells reverses or prevents a wide range of diseases, including osteoarthritis, atherosclerosis, eye diseases, and kidney diseases.1

1. UNITY公司官网

1. UNITY official website

图片：摘录自科学杂志第354卷6319期

Pictures: excerpts from Science, Vol 354, Issue 6319